Cultural Activity Report Essay Example | Topics and Well Written Essays - 500 words - 1

Cultural Activity Report - Essay Example In fulfillment of the requirements of this course, on 15th/03/2014, I took my time and attended a live concert at the City Auditorium. This was a spectacular event organized by the National Jazz Promoters which features the renowned Jazz Band of America. As a student, I had to attend this show in order to have a first-hand encounter with this high school-students-dominated band. It was indeed a great experience because it exposed me to lots of entertainment that I had never enjoyed before. With the National Jazz Promoters at the helm of the concert, everything went as planned. I was very excited and anxious to come across great figures like David Alex Lacy, Joel Gardella, Aaron Mutchler, Josh Achiron and Max who have made a name in the music industry. Even before the beginning of the event, my attention was captured by the theatre. For sure, the event was organized in a very spacious theatre equipped with modern facilities including chairs, stage, auditorium and laser lights. Meaning, all the fans that had thronged the venue would be easily accommodated without any problem. Besides, there were still enough spaces in which everyone would get to dance and enjoy the sweet melodious songs played by these artists. I was impressed by the manner in which these artists entertained us. Each of them seemed to have been adequately prepared for their respective roles which they played excellently. Meaning, the conductor, vocalists, singers, dancers and the instrumentalists were quite articulate in their performance. Everything was properly coordinated to help in producing sweet sounding rhythms that could be enjoyed by everyone. As a matter of fact, I was particularly delighted by the performances of Phillip Ahn who played the saxophone; Nathaniel McKay who played a trumpet; guitarist Josh Achiron and the pianist Max Holm. Their participating in the concert was so entertaining. A part from these instrumentalists, the singers also displayed a

Research a design work or designer in the world Paper

A design work or designer in the world - Research Paper Example Ive introduced colour and light to the computing world, something that had not been seen before. Before the arrival of Ive’s iMac, most computers then were black and white. It was this ambiance in design that enabled Apple to sell two 2 million units in its first year. Sir Jonathan Ive joined Apple when the company was on the decline after ousting of its co-founder, Steve Jobs. This is because the company had seemed to lose its identity and purpose. But upon the return of Steve Jobs as CEO, this time marked the greatest contribution of Ive to Apples’ future. Some of his design work then as the vice president of industrial design included the iMac in 1998, the iBook, the cinema display, iSub and PowerMac G4. The Apple G4 Cube was released in the year 2000 under his watch and later the iPod in 2001. He is also behind the design of products like MacBook Pro, MacBook Air, iPod Touch, iPad and iOS7. In 2002, he introduced a newer version of the iMac specifically designed for the education sector. Other notable design works of Jonathan Ive at apple included the Apple PowerBook released 2003, the iPod mini and ultra-slim iMac and later the iPhone and the iPad. Sir Jonathan Ive has had a tremendous impact not only on the company’s productivity but also on the design team. Apple focuses on designing of range of products that include components such as speakers, mouse, headphones and computers. The company focuses on technology based products. Ive’s impact at Apple has been tremendous with his design tricks that are based on understanding the user’s behavior and need. He is responsible for ensuring design is part and parcel of personal computers and other handheld devices as their processing power and speed. For instance, in his quest for design of the iPod, his philosophy was to have a gadget that completely overturns the user’s previous experience and letting them understand the aspect of storing

Mechanisms in the Cardiovascular System

Mechanisms in the Cardiovascular System The mechanism of the pumping action of the heart can be categorized in three phases- the generation of an action potential, conduction of the action potential and cardiac muscle contraction (action potential-contraction coupling). The action potential is generated the specialized autorythmic myocardial cells located at the Sino atria (SA) node. The potential spreads to the atria and enters the ventricles through the atria ventricular (AV) node from where it is conducted throughout the ventricles by the bundle of His and the purkinje fiber. The action potential triggers muscle contraction as it sweeps around the heart1. As the cardiac muscles contract and relax the heart beats repeatedly, in the process receiving and pumping blood, first to the lungs then to the rest of the body. As it leaves the heart, the blood carries with it oxygen and nutrients to the body and brings back metabolic wastes from the body cells 1, 2. However, much as it supplies blood to the rest of the body, the heart itself needs blood to support its metabolic activity. The heart is thus supplied by the coronary arteries which branch off from the aorta. Reduction in the volume of this coronary flow can greatly impair the pumping action of the heart and if not treated, can cause heart failure. A number of treatment options ranging from surgical to drugs are available2b. THE CARDIOVASCULAR SYSTEM The cardiovascular system is an organ system responsible for distribution of nutrients and oxygen to the bodys cells and removal of metabolic byproducts from the cells. It consists of the following: Blood which carries nutrients and oxygen to the cells and metabolic byproducts away from the cells The blood vessels which are the pathways through which blood flows The heart which receives and pumps blood. Embedded in the heart are valves that control blood flow and ensure that blood flows in a specified direction3,8. THE HEART In brief, the heart is a muscular organ enclosed in a double walled sack called the pericardium. It is about the size of a fist and weighs between 250 grams and 350 grams. It is located within the medial cavity of the thorax between the second and fifth intercostal space, just on the superior surface of the diaphragm, anterior to the vertebral column and posterior to the sternum7. The heart is divided in four chambers, the right and left atria, the right and left ventricle. The circulation process is such that the right atrium receives blood from the rest of the body through the venacavea and feeds it to the right ventricle which pumps it to the lungs through the pulmonary artery to be oxygenated. Blood from the lungs comes back to the left atrium through the pulmonary vein and finally to the left ventricle. The left ventricle pumps blood to the rest of the body though the aorta and arteries7,1. The Mechanism of Heart function The most important function of the heart is to pump blood. The mechanism by which the heart pumps blood can be understood by examining the events that lead to cardiac muscle contraction. The contraction process starts with the generation of an action potential from the sinoatrial (SA) node giving rise to a depolarization wave. The wave spreads through the atria, entering the ventricles through the atrioventricular (AV) node and is conducted throughout the ventricles by the bundle of His and the purkinje fibers1. Generation of action potential. The heart is composed of two kinds of cardiac muscle cells- the contractile and autorythmic cells. The contractile cells are responsible for the mechanical work of pumping and therefore form the bulk of the cardiac muscles. However, these cells need to be excited before they can contract. Highly specialized autorythmic cells are responsible for generation and conduction of the excitation signal-the action potential1,3. These autorythmic cells are found in specific regions of the heart that include: The SA node. This is a small region located at the upper wall of the right atrium. The AV node. This is a bundle of the autorythmic cells found at the lower wall of the right atrium, near the septum that separates the atria from the ventricles. The bundle of His. This is a bundle of specialized conductive cells that originate from the AV node and runs down the septum between the ventricles. It separates into the right and left bundles serving the respective ventricles. The purkinje fiber. These can be regarded as terminations of the bundle of His. They spread over the base of the ventricles.The locations of the autorythmic cells are the origin and pathways of the action potential3. The cardiac action potential The SA node is the pace maker of the heart. It sets the frequency at which the heart beats. Looking at the cardiac cell, the action potential starts by the reorganization of the intracellular and extracellular concentration of potassium, sodium, chloride and calcium ions due to changes in the cell membrane permeability. A graph showing a typical myocardial cell action potential is shown in figure 1 below. Figure 1: Cardiac cell action potential. Source4: As in the graph, the different phases represent different stages of depolarization of the cardiac cell. Phase 4: In this phase, the cell is at rest. In the resting state, the cell membrane is more permeable to potassium and therefore the resting potential is more or less equal to the potassium equilibrium potential (-90mV). Phase 0: As the potential slowly rises, the voltage-gated sodium channels open leading to a rapid influx of potassium into the cell causing rapid depolarization. At the same time, the membrane permeability to potassium slowly reduces as the potassium channels close. This process takes the membrane potential to around +20Mv before the sodium channels suddenly close. Phase 1: On inactivation of the sodium channels, potassium continues to leak out of the cell and chloride ions go into the cell causing a small downward deflection of the action potential. Phase 2: At this stage, there is increased permeability of the membrane to calcium ions. The inward calcium movement is balanced by an outward movement of potassium ions accounting for the relatively flat phase 2. Phase 3: An increase in the permeability of potassium outweighs the inward calcium current and eventually tips the potential of the cell. This is the repolarization phase and the cell goes back to its resting potential, phase 43,4. Excitation-contraction coupling As described in muscle contraction, the action potential-contraction coupling is due to the release of calcium from the cells sarcoplasmic reticulum. The calcium combines with troponin which regulates the tropomyosin, removing it from the binding site. This allows myosin to bind to actin thus making the muscle to contract3. The cardiac cycle The depolarization and repolarization of the cardiac cell described above triggers the contraction and relaxation to the atria and ventricles of the cell. The cardiac cycle is divided in two main phases, diastole which is the period of relaxation and systole which is the period of contraction. Systole. During this phase, the depolarization wave starts from the SA node, spreading first through the atria and causing the atria to contact first. This forces blood from the atria to the ventricles. At this time, the atrioventricular valves are open while the pulmonary and aortic valves are closed. The depolarization wave then enters the ventricles through the AV node, spreading over all the ventricles via the specialized conductive bundle of His and the purkinje network. This causes the ventricles to contract forcing the blood to the lungs through the pulmonary vein and the rest of the body through the aorta. Here the atrioventricular valves close while the pulmonary and aortic valves open5,3. Diastole. After contraction of the atria, the cells are repolarized. This allows the atria to relax thus allowing blood to flow into them through the vena cavea. After the ventricular contraction, the ventricles also relax awaiting to be filled with blood from the atria5. THE CIRCULATORY SYSTEM The circulatory system is part of the cardiovascular system and is divided into the pulmonary circulation and systemic circulation. The pulmonary circulation transports deoxygenated blood from the heart to the lungs and returns oxygenated blood from the lungs to the heart9. The systemic circulation transports oxygenated blood from the heart to the rest of the body and brings back deoxygenated blood from the body back to the heart9. Deoxygenated blood enters the right atrium from the vena cava and flows through the tricuspid valve into the right ventricle. It is pumped from the right ventricle through the  pulmonary semilunar valve  into the pulmonary arteries which go to the lungs. Oxygenated blood returns via the pulmonary veins and enters the left ventricle through the mitral valve. It is the pumped through the aortic valve, to the aorta then through the arteries to the rest of the body. It is evident that oxygen is very important in metabolic activity of the body cells 3,9. Transport of oxygen by the cardiovascular system The red blood cells. One of the functions of the cardiovascular system is to distribute oxygen around the body. Oxygen is carried in blood by the red blood cells. Understanding the structure of the red blood cells will help us to understand how it is able to carry oxygen. The molecule of a red blood cell is composed of four polypeptide chains with each polypeptide chain having an iron-containing heme group. Each of the four iron atoms can combine reversibly with oxygen according to the equation: O2+Hbà ¢Ã¢â‚¬  Ã¢â‚¬ HbO2. It is therefore possible that each molecule of hemoglobin can carry up to four molecules of oxygen1b,2b. Oxygen uptake Blood is pumped from the right ventricle to the lungs to be oxygenated. In the alveoli, the partial pressure of oxygen is higher than that in the blood and the partial pressure of carbon dioxide in the alveoli is lower than that in the blood. The pressure differences make it possible for oxygen to diffuse from the alveoli to the blood, thus binding to the iron in the hemoglobin. Carbon dioxide on the other hand diffuses from the blood to the lungs. Carrying oxygen, blood is returned to the left atria then to the left ventricle which pumps it to the rest of the body2c. Oxygen release: In the tissues and organs, the cells are undergoing metabolism, continually consuming oxygen and releasing carbon dioxide. This means that the intracellular partial pressure of oxygen is lower than that in the blood and the intracellular partial pressure of carbon dioxide is higher than that in the blood. Again the pressure differences make it possible for oxygen to diffuse from the blood to the cells and carbon dioxide from the cells to the blood, binding again with the iron in the hemoglobin. Therefore, as blood flows around the body, it continually distributes oxygen2c,6. BLOOD SUPPLY TO THE HEART Coronary flow In order to perform its functions, the heart an abundant supply of oxygen and nutrients and therefore needs a dedicated supply of blood. Coronary circulation is that part of the systemic circulation that provides blood supply to the heart. Just as the aorta leaves the left ventricle, it gives of the right and left coronary arteries9. The left coronary artery divides into smaller braches supplying blood to the apex and the posterior side of the heart, the ventricles and part of the anterior interventricular septum, the left atrium and posterior wall of the left ventricle. The right coronary artery supplies the lateral aspect of the right atrium and ventricle, the posterior wall of both ventricles and the SA node9,10. Effect of reduced coronary flow on cardiac function The energy demand of the cardiac muscle is so crucial that an interruption of blood supply to any part of the myocardium can cause necrosis within minutes9. A decrease in coronary flow to levels below normal is called myocardial ischemia. The ischemia can be caused by vascular spasms of the coronary arteries, atherosclerosis or increased activity of the heart beyond levels that the coronary arteries can supply10. Temporary or reversible obstruction of coronary blood flow can cause chest pain known as angina pectoris9. Chronic myocardial ischemia can lead to myocardial infarction where myocardial cells die and are replaced by scar tissue. Reduced coronary flow therefore can affect cardiac function in several ways. If the heart is not able to meet its metabolic demand, it can be understood that it will not be able to pump enough blood to the body. Reduced blood flow to the rest of the body can result in serious physiological and pathological conditions which are beyond the scope of this essay. With the death of some cardiac cells as in the case of chronic ischemia, several other life threatening conditions can arise which affect cardiac function. One of such dangerous conditions is ventricular fibrillation which is an abnormal pulse generation triggered by the damaged myocardial cells. The heart will not be able to pump blood but will just quiver around without any net output. Death can occur within minutes2b,6. Treatment of reduced coronary flow Other immediate effects like ventricular fibrillation caused by reduced coronary flow can be treated by defibrillation. However, the main cause of reduced coronary flow is coronary artery occlusion or restriction and the following treatment options are available: Coronary bypass: This is a surgical technique where the occluded coronary artery is cut and replaced by a new blood vessel, usually a vein taken from somewhere in the patients body2b. Coronary balloon angiography (cardiac catheterization): This is another surgical procedure where a catheter containing a balloon at its tip is passed into the occluded artery. The balloon is enlarged thus stretching the artery and opening it in the process2b. The use vasodilator drugs such as nitroglycerine: These drugs dilate the coronary artery thereby lowering the total peripheral resistance. This reduces the work the heart must do in ejecting blood. This is usually given to people who have already suffered myocardial infarction to reduce the risk of another occurance2b,10. A person at risk of myocardial infarction can be put a low cholesterol, low fat diet to reduce the risk of atherosclerosis and takes aspirin to reduce the risk of blood clot formation. Conclusion The cardiovascular system is one of the most important systems of the body. All the other systems and organs of the body depend on it for supply of oxygen and nutrients and removal of metabolic wastes. The heart acts as a pump to make sure blood is circulated to all parts of the body through pulmonary and systemic circulations9. However, the heart itself needs supply of blood in order to perform its main function of pumping blood and the heart is supplied by the coronary circulation. Reduction in coronary flow means the heart will not be able to meet it metabolic needs and therefore cannot pump enough blood. This can adversely affect normal activity of the body and cause death10. References Sherwood L. Fundamentals of physiology a human perspective. St. Paul Minn: West publishing company; 1991.190-199 1b. Sherwood L. Fundamentals of physiology a human perspective. St. Paul Minn: West publishing company; 1991.263-266 Vander A, Sherman J, Luciano D. Human physiology, the mechanisms of body function, seventh edition. Boston: McGrow-Hill; 1998. 387-389. 2b. Vander A, Sherman J, Luciano D. Human physiology, the mechanisms of body function, seventh edition. Boston: McGrow-Hill; 1998. 374-377. 2c. Vander A, Sherman J, Luciano D. Human physiology, the mechanisms of body function, seventh edition. Boston: McGrow-Hill; 1998. 479-483. Koeppen M B, Stanton A B. Berne and Levy physiology, sixth edition. Philadelphia, PA: Mosby/Elsevier; 2008. 289-303 Serguei Semenov (2009): Lecture notes. Physiological measurements, ecg/pacemakers/defibrillators. Cohen J B, Wood L D. Structure and function of the human body, seventh edition. Philadelphia: Lippincott Williams and Wilkins; 2000. 195-204. Vandegriff K.D, Benazzi L, Ripamonti M, Perrella M, Tellier Le Y.C, Zegna A, Winslow R M. Determination of the rate and equilibrium constants for oxygen and carbon monoxide binding to R-state human Hemoglobin,199: The journal of Biological Chemistry ; 266 (26): 17049-17059 Elaine N M, Katja H. Human anatomy and physiology, seventh edition. Menlo Park: Benjamin Cummings; 2007.674-681 Sherwood L. Human physiology: from cells to systems, sixth edition. Belmont, CA: homson/Brooks/Cole; 2007.300-304 Saladin K S. Anatomy and physiology: The unity of form and function, fifth edition. Maidenhead: McGraw-Hill Higher Education; 2009.683-755 Stanfield C L, Germann W J, Niles J N, Cannon J G. Principles of human physiology, third edition. San Francisco: Pearson/Benjamin Cummings; 2009. 361-366 Skeletal Muscle Question: Describe the structure of skeletal muscle and how it contracts (90) and discuss a disease that may arise from this system (10) The structure of skeletal muscle and the mechanism of muscle contraction including muscle disease (1553 Words) 1.0 ABSTRACT Skeletal Muscle is a form of fibrous tissue with the fibers arranged parallel to each other. A muscle fiber (cell) is surrounded by the endomysium. A group of these cells is wrapped by fascicles. Bundles of fascicles are covered by the perimysium and bundles of the perimysium are wrapped by the epimysium to form a muscle. The muscle fibers have contractile properties which enable them to move bony levers in order to produce skeletal movement1. The functional unit of the muscle fiber is the sacomere which consists of most importantly, actin and myosin. The actin and myosin are arranged such that during contraction, they can slide over each other thus shortening the muscle2. Muscles suffer from many diseases, one of which is polymyositis. This is an inflammatory myopathy that affects mainly the muscles of the thorax and those around the torso. It affects all age groups but has been noticed mainly in late childhood and early adulthood. The sypmtomps are nonspecific but results in general muscle weakness and the cause, though believed to be an invasion by the white blood cells, is not very clear10. 2.0 The Structure of Skeletal Muscle. In daily life, structures and arrangements of designs are dictated, to a large extent by the purpose and function for which the design is meant for. Knowing that skeletal muscle is made up mainly of fibrous tissues, the arrangement of these tissues and how they are bound together to maintain a particular shape in order to accomplish different purposes (mainly to generate force and produce movement) may to a large extent, define the structure of the muscle4. At a macro level, the skeletal muscle is composed of bundles of individual muscle fibers, the supporting structure called the basal lamina, and the connective tissue sheaths as shown in figure 1. These connective tissues bind the cells together giving them strength and partly providing mechanical protection2. We can examine these connective tissues and their functions as follows: 2.1 The basal lamina. This is an extracellular matrix that acts as a scaffold on which a cell sits. It has been realized that apart from providing structural support, the basal lamina can orient and constrain cell during the process of regeneartion3. 2.2 The endomysium. This is a fine sheath of connective tissue that surrounds each individual muscle cell. The endomysium consist of loosely interlacing fibers composed mainly of collagen4. 2.3 The perimysium and fascilces. The individual muscle fibers wrapped by the endomysium, are grouped together in what is called fascicles. A layer of fibrous tissue called the perimysium wraps each fascicle4. 2.4 The epimysium. This is the outside layer that finally wraps the whole muscle. It is composed of dense irregular connective tissue4. Figure 1 Source: http://www.web-books.com/eLibrary/Medicine/Physiology/Muscular/muscle_structure.jpg 3.0 The muscle cell Having described how individual muscle cells are organized into a muscle, it is imperative that we look at the structural composition of the cell itself. Just like many other cells in the body are specialized according to their functions, skeletal muscle cells are specialized to produce force and movement5. The skeletal muscle fiber is thus composed of mainly three structural elements:-the myofibrils, the sarcoplasmic reticulum and the mitochondria, each contributing a unique aspect of muscle function. The entire function of the muscle can be attributed to the shifts in proportions of these three structures6. 3.1 The Myofibrills. These are cylindrical specialized sub-units within the muscle fiber. They consist of two types of contractile protein filaments-the thin filaments referred to as actin and the thick filaments referred to as myosin. The two most important parameters of the myofibrils are their diameter which determines its strength and the fiber length which determines it contraction velocity and distance over which the fiber can contract. The myofibril consist of two filaments-actin and myosin6,2. 3.1.1 Actin (thin filament). Actin filaments are responsible for regulation of contraction. The actin filament is formed by a helical arranged of actin monomers which is an ambiguous protein2 (figure 2). Because of the helical nature, a long grove is formed along the filament and the protein troponin is located at intervals along the length of the actin filament. It is troponin which is responsible for turning on contraction2,7. Figure 2.The actin molecule. Source: http://www.ucl.ac.uk/~sjjgsca/Muscleslidingfilament1.gif 3.1.2 The Myosin (thick filament). Myosin filament is about 150nm long. It has a tail and two heads. The tail is formed by two helical shaped fibers that coil around each other. A collection of several of these helical tails together form a myosin filament (figure 3)4b. Figure 3. The myosin molecule. Source: http://webanatomy.net/anatomy/myosin.jpg. 3.2 The sarcoplasmic reticulum (SR). Groups of about 200 thick and thin filaments constitute a myofibril. Each myofibril is thus enclosed in a membrane called the sarcoplasmic reticulum8. The SR membrane stores and releases calcium during muscle contraction and relaxation. The SR can therefore be thought of as the functional unit of the myofibril9. 3.3 The mitochondria. Found within the cell cytoplasm, the mitochondria are responsible for generation of most of the cells energy by the production of adenosine triphosphate (ATP). There are several mitochondria distributed along the length of a myofibril4. 4.0 The mechanism of muscle contraction Muscle contraction can largely be attributed to the structure of actin and myosin, their arrangement within the SR and the interaction between them in order to produce force (Figure 4). This type of arrangement allows the thin actin filaments to slide in and out by the action pull of the myosin heads8b. Figure 4. Actin and myosin arrangement: Source: http://www.exrx.net/Images/ActinMyosin.gif Muscles are composed of a number of actin and myosin filaments arranged in series in a basic unit called the sacomere. The sacomere consists of a thick filament in the meddle and two thin filaments, one overlapping on each side. The heads of the thick filament attach to the thin filament at the overlap and these heads allow movement in only one direction. When activated, each thick filament head rachets repeatedly along the actin, pulling the two actins closer together. Since the actin are attached to the Z line (The distance between two Z lines form the sacomere), ends of the sacomere (Z lines) are pulled in and the sacomere shortens. The sacomeres are arranged in series so that when the muscle fiber contracts, all the sacomeres contract simultaneously transmitting the force to the end of the muscle. The whole process of contraction described above occurs when the muscle is electrically stimulated2b. 5.0 Muscle stimulation. Skeletal muscle cells are stimulated by the motor neurons of the somatic nervous system. The reception of the motor stimulus (action potential) opens the calcium channels allowing calcium which is stored in the SR to be released. The release of calcium causes the release of acetylcholine-Ach (neurotransmitter). The calcium binds to the troponin on the actin filament. Troponin then regulates the tropomyosin which obstructs binding sites for myosin. This allows the tropomyosin to move, unblocking the bonding site. Myosin then binds to the unblocked site on the actin and applies a pull. This will pull the Z bands towards each other thus shortening the sacomere, causing muscle contraction2b. However, as calcium is released, the ATP-dependent calcium pump is activated and it continuously pumps calcium back to the SR to be stored again. This leads to a drop in calcium level within the cytoplasm. When the calcium level is too low, the calcium binding action to troponin is terminated, releasing tropomyosin which again blocks the binding site. This stops the interaction between actin and myosin thus relaxing the muscle2b. 6.0 Muscle Diseases There are a number of muscular diseases and disorders ranging from acquired, familial to congenital. Limiting ourselves to one of the acquired disorders of the muscles, lets look at polymyositis. 6.1 Polymyositis (PM). PM is a type of muscle inflammatory myopathy. Just like the name suggests, this disease causes inflammation of the muscle fiber. Although the causes of the disease are not well understood, it is believed that PM begins when white blood cells, spontaneously invade muscles. This can result in severe muscle weakness. Polymyositis is a persistent disease characterized by periods of increased and reduced or no symptoms. PM affects mainly the muscles of the thorax and is more common in women than men. It is said to affect all age groups although is it commonly noted in early childhood or 20s10. Key pathologic and diagnostic features of the disease. Endomysial inflammation. This is the inflammation of the outer connective tissue that surrounds the muscle fiber. This is done by the white blood cells that leave the blood and enter the tissue, somehow confirming the earlier assertion that the PM begins when white blood cells invade muscles. Invasion of myofibers by autoaggressive lymphocytes. This is when the T lymphocytes begin to attack the intact myofibers. Unlike in muscle dystrophy where inflammation is associated with degenerating myofibers, the invasion of T lymphocytes causes inflammation of health myofibers in PM.This causes inflammation of healthy myofibers. Other diagnostic features that may not be exactly specific to PM include myofiber necrosis, myophagocytosis, myofiber atrophy and fibrosis, a feature of chronic PM10,11. 7.0 Conclusion Human movement is only possible because of the action of muscle contraction. Voluntary contraction of muscle is made possible by the somatic nervous system which sends out an action potential activating the contraction process. The process is accomplished by the sliding of myosin and actin over each other. Many diseases and disorders affect muscles, prominent among them is muscular polymyosis which causes inflammation of the muscles mainly around the torso. Its believed to be caused by the unwanted action of the white blood cells and the symptoms include muscle weakness.

Comparing Immorality in The Rise of Silas Lapham and The Octopus Essay

Motivation of Immorality in The Rise of Silas Lapham and The Octopus      Ã‚  Ã‚   In both William Dean Howells' The Rise of Silas Lapham and The Octopus by Frank Norris, a character is faced with the moral issues involved with operating his business. Howells' character, Silas Lapham (The Colonel) and Norris' Magnus Derrick are both desirous to have a prominent position in their respective societies, but are in the precarious situation of having to deploy immoral methods to achieve this coveted stature during the course of harder times. Each man has aspirations to be powerful, prestigious, famous, and/or wealthy. In combination with their lack of humility for their lofty position in society and their over ambitious definition of success, both are caused great distress on the path and during the fight to reach this egotistic plateau. The image created through their business venture became the primary tool to evaluate their own personal vision of success, and in doing so, the two men's morals and values became tainted, family relations were hurt and even devastated, in addition to creating social debacles that caused incredible harm to many others.   Ã‚  Ã‚  Silas' background consisted of poverty, hardships, and hard work. He acquired his own wealth and that opened doors that were unknown to him or his family. The Colonel's background and attributes led him into an awkward situation of always attempting to appear in society as something that he is not. He is a common, vulgar man, doing his best to appear sophisticated, educated, and knowledgeable, when, in fact, it is only his wealth that connects him to the upper class. His incredible wealth places within him the motivation and false sense of obligation to conform to the tastes and pre... ... or power or fame. The path to attain these goals is often filled with corruption, heartless doings, and unsympathetic forces. To see past material possessions and to crush one's ego and its self-centeredness should be sought. To accept one's lot in life and attempt to not control forces outside of one's power or nature should be admired. Being concerned with one's family as a primary responsibility and acting accordingly should be hailed an accomplishment. To face an evil force sweeping into one's reality and being able to hold onto one's morals and values in spite of it, an achievement.   Works Cited Howells, William Dean. The Rise of Silas Lapham. New York: Signet Classic, 1983.. Marx, Karl. "The Alienation of Labor." Economic and Philosophic Manuscripts of 1844. Richard Hooker, 1996: 1-9. Norris, Frank. The Octopus. New York: Penguin Books, 1986.

Mass Media and Economic Development Essay

Mass media has always been one of the pillars of modern society. With its wide range and base, it is indubitably, the most effective and efficient way of mass information dissemination. Yet, instead of mass media being a primary tool for education, it is mostly being used as a medium for entertainment; to show bland, superficial products with little, or no educational value. So, attempting to connect mass media with economic development would seem as disjoint as climate change and my inability to make good analogies. Surprisingly, this is what the last speaker, from ‘The Public Sphere’ talked about. The forum cites economic literacy as the main contribution that mass media can make to economic development. Defining economic literacy as ‘the ability to identify, analyze and evaluate the consequences of individual decisions and public policy,’ the speaker, Mr. Omar Dumdum of NEDA, goes in to explain the ineffectiveness of economic education in secondary school; therefore, mass media should take the primary responsibility of promulgating economic literacy, to promote economic development. This can be done, according to Mr. Dumdum, through better economic news writing and reporting, making economic news understandable for the general population, and information dissemination campaigns. There will be some difficulties encountered, of course, as Economics is wrought with technical terms that cannot be easily simplified, but, if information campaigns are done in tandem with better reporting, results can be achieved. Personally, I do think it is possible and feasible. Being someone who believes in the power of mass media to reform society, I think mass media could enhance the net economic literacy of the Philippines, which would, hopefully, increase Filipino participation in crucial economic activities, resulting in inclusive economic development. But of course, mass media has internal flaws that prevent this from happening. For one, it bears the inability to make economic news/information exciting, or even understandable. If not for my privileged secondary and tertiary education, I would not know anything about our country’s economic status, as I regularly skip the Business section of the papers, because it is simply boring. Economic reporting tends to be too technical, or elitist, so much so, that for the average Filipino citizen believes that the economic opinion of his/her neighborhood barber is more valid and believable compared to the TV guy in a suit. I am not dismissing the opinion of Manong Barber as incorrect or irrelevant (he might be an economist, who knows), but this points out the preference of Filipinos to opinion-based economic information, over rigorous, empirical economic reporting. And, so I have mentioned, we Filipinos are not entirely at fault. We cannot be blamed for giving more importance to comprehensible information than jargonic ‘gibberish.’ Also considering the fact that public opinion greatly influences economic policies in our country (i.e. sin tax bill), this, all the more makes the media’s role in promoting economic development crucial. I do agree with Mr. Dumdum’s proposed approach of information campaigns being conducted simultaneously with better news reporting, because better enws reporting alone would not fulfill the expected impact of mass media in the economic literacy of our society. In conclusion, I think that the mass media, is indeed, an important element in aiding the development of a Philippines as a globally competitive economy. It is not enough, however to merely educate people about the Economics and the economic condition of our country at present. Public policies, political will, exhaustive analyses and correct decisions are also parts of the solution to the enigma that is Philippine development. And, in these, mass media can only contribute so much; mass media cannot improve the Philippine economy alone.

Linguistics and Structuralism Essay

Structuralism is a mode of thinking and a method of analysis practiced in 20th-century social sciences and humanities; it focuses on recurring patterns of thought and behaviour ? it seeks to analyse social relationships in terms of highly abstract relational structures. Structuralism is distinctly different from that applied to Radcliffe-Brown? it involves more the bio and psychological aspect of human studies rather than social structures. Claude Levi-Strauss was the one to pioneer structuralism; he suggested that cultural phenomena such as myths, art, kinship systems and language display certain ordered patterns or structures. With these, he believed that the structure of the human mind could be revealed. He reasoned that behind the surface of individual cultures there must exist natural properties common to us all: innate structures universal to all man. Levi-Strauss focused his attention on the patterns or structures existing beneath the customs and beliefs of all cultures. Methodologically, Strauss drew his models from structural linguistics, analysing forms of social activity as though they were languages. In other words, the things a society does, the way people in this society act, is compared to language; behaviour is acted out unconsciously as is grammar in the case of language. Therefore, societies differ just as grammar differs between one culture and another, but what Levi-Strauss sought was the universal/common structure behind it. He believed that while the surface phenomenon may vary, the underlying ordering principles are the same. Levi-Strauss believed that basic thinking occurs as sets of contrasts. All cultures think in to terms of opposites so as to classify-meaning we must be able to distinguish between things. For example, life, death; spirit, body; black, white; red, green (stop and go) ? these words alone do not carry much significance; they have a meaning and that’s it ? basic facts. We take the words as they are by use of external references from what society acknowledges to it to be. A pen is not an eraser because society has accepted it to be a pen. Levi-Strauss argued that culture is to be understood as a surface phenomenon which reveals the universal human tendency to order and classify experiences and dynamics. He compared people’s language to the?  rules’ that govern society, in that the governed are largely unconscious of what they know. He compared speech – the use of sounds and rules, mainly in the form of sentences to the ideas and behaviour that result from the application of largely unconscious social rules. Members of a society are much more likely to be conscious of their actual ideas and behaviours than they are of the deeply structured rules that make these ideas and behaviours possible, but the ideas and behaviours of a given group of people, according to Strauss, can only be understood once the â€Å"deep† structures in their minds can be discovered. He says that human responses are largely dissimilar, and that the surface structure is what will consequently show different cultural behaviour. In T. O. K. , we are currently discussing language, mind and meaning ? we covered the same man, Noam Chomsky, the same man mentioned in the book. He pursued the same line of inquiry in linguistics as Strauss. Chomsky believes that the human brain contains a language system base before birth, but ? goes to seed’ if not stimulated after birth. All babies are programmed to all phonetic systems but are channelled into particular language groups on socialization. In other words, a child who has Danish parents will eventually end up speaking Danish unless brought up elsewhere. Structuralism is often criticized for not being able to prove something through hypothesis testing and validation. Strauss makes unprovable assumptions about humans, and some people find it hard to believe the concept of universal structures. Structuralism also tends to ahistorical, thus not accounting for the way history effects the present.